Sileo Dose In Cats

Hypertension in Cats

• If cats have pale mucous membranes and unacceptably slow pulses (less than 80 bpm) or hypotension - stimulate them by handling and if this does not resolve the problem administer 10 to 20% of the calculated atipamazole dose IM. If you feel that the cat is in crisis, the full atipamazole dose can be given IV slowly by titration over 2.
• INDICATIONS: SILEO is indicated for the treatment of noise aversion in dogs. DOSAGE AND ADMINISTRATION: SILEO is administered onto the oral mucosa between the dog's cheek and gum at the dose of 125 mcg/m2. The gel is absorbed through the oral mucosa and therefore it should NOT be swallowed. If the gel is swallowed, the product may not be.

A silent disease

Sileo is packaged in an oral dosing syringe with a ring-stop mechanism on the plunger that must be 'dialed' and locked into place in order to set the correct dose for the dog. Overdose can. Sileo Indications. SILEO is indicated for the treatment of noise aversion in dogs. Dosage and Administration. Always provide the Client Information Sheet with SILEO and instruct the client how to properly operate the SILEO dosing syringe (see Client Information Sheet for Owner/Handler Use and Safety).

While hypertension can be a common problem in older cats, the condition can be difficult to diagnose.^3,4

Hypertension can affect many parts of the body before detection and is strongly associated with target organ damage^3,4:

• Eyes
• Heart and vascular system
• Brain
• Kidneys

Without treatment, this silent disease can lead to serious illness and, sometimes, death.^3,4

Most often develops as secondary hypertension to diseases such as CKD and hyperthyroidism.³

Efficacy

Proven to lower systolic blood pressure^1,10

A pilot dose determination laboratory study was conducted to evaluate the effectiveness of multiple oral doses and dose strategies of telmisartan on the reduction of systolic blood pressure (SBP) in clinically normal, healthy laboratory cats within a 14-day time period.¹¹

* Endpoint at day 14 was significant reduction from baseline compared to placebo (P < 0.0005).

† A clinically relevant reduction in group mean SBP was predefined to be ≥ 20 mmHg in the telmisartan group from baseline to Day 28. The number of cats available at Day 28 for comparison is less than at enrollment because of removal of cats for hypertension rescue or adverse reactions.

The only angiotensin receptor blocker (ARB) for first-line treatment of hypertension in cats

Sileo For Dogs Reviews

Because ARBs feature a unique, targeted mode of action that specifically blocks the harmful vasoconstrictive effects of the renin-angiotensin-aldosterone system (RAAS), SEMINTRA is shown to quickly lower blood pressure within 14 days‡

• Shown to be effective in cats with primary and secondary hypertension
• Proven to be safe and effective^10–13

Safety and Dosing

Flexible dosing to safely lower and maintain blood pressure in cats

• SEMINTRA offers a dose-dependent response—an initial 1.5 mg/kg (0.68 mg/lb) dose twice daily for 14 days lowers blood pressure to a healthy level quickly, followed by a 2 mg/kg (0.91 mg/lb) once daily dose to maintain control¹¹
• Dose may be reduced by 0.5 mg/kg (0.23 mg/lb) increments to a minimum of 0.5 mg/kg to optimize dosing and prevent hypotensive state

Easily given as oral liquid

Easy-to-use Syringe

— Flexible delivery of dose straight into the mouth or on top of food²

— Selection of accurate dose

Safe for long-term administration

— Safety shown to extend through 6 months in multiple studies^10–13

Convenient liquid formulation

As demonstrated in a study:

— 91.2% of cat owners perfer a liquid formulation²

Mode of Action

Sileo Side Effects

SEMINTRA is a highly targeted treatment

Telmisartan, the active substance in SEMINTRA, is an ARB, a class of medication that modulates the RAAS by selectively blocking receptors in the effector step of the RAAS. Unlike angiotensin-converting enzyme inhibitors (ACEis), ARBs do not block the conversion of angiotensin I to angiotensin II by angiotensin-converting enzyme in the RAAS cascade, thereby also blocking the activation of some of the receptor types with beneficial effects. And, unlike a calcium channel blocker, a class of pharmaceuticals that block the influx of calcium into cardiac and smooth muscle cells through calcium channels and potentially activate the RAAS, ARBs help to manage the RAAS.

Chronic activation of the RAAS can be harmful to tissues, including the kidney.

Watch this video for more information

• Activation of RAAS can be complex, but conditions like chronic kidney disease, cardiac disease, and hyperthyroidism typically increase RAAS activity
• Chronic, excessive RAAS activation can result in systemic hypertension because it promotes salt and water retention and increases blood pressure^14,15
• ACEis reduce the conversion of circulating angiotensin I to angiotensin II, which reduces all of the effects of angiotensin II at all receptors
• ARBs have a more targeted mode of action. They bind only to the AT₁ receptor, preventing activation of this receptor by angiotensin II
• Because ARBs do not bind to AT₂ receptors, the potentially beneficial effects of angiotensin II at these receptors are preserved

Sileo Dose In Cats Food

Watch this video for more information

Target-specific mode of action of ARBs

Shorten (SHN) is a file format used for compressing audio data. It is a form of data compression of files and is used to losslessly compress CD-quality audio files (44.1 kHz 16-bit stereo PCM). Shorten is no longer developed and other lossless audio codecs such as FLAC, Monkey's Audio(APE), TTA, and WavPack (WV) have become more popular. Jul 20, 2015 To complete the above tasks, Faasoft's wonderful SHN Converter for Mac and Windows is a nice choice. With the help of this powerful SHN Converter, you can convert SHN files to FLAC, MP3, WAV, M4A, AIFF, ALAC, CAF, DTS, AAC, etc effortlessly. Jul 09, 2020 shn to flac converter free download. Fre:ac - free audio converter fre:ac is a free audio converter and CD ripper for various formats and encoders. It features MP3, MP. Shn converter free download - MediaHuman YouTube to MP3 Converter, Free YouTube Converter, Xilisoft Video Converter Ultimate, and many more programs. Tags: shn to flac, shn to mp3, shn converter, shn to wav, convert shn to mp3, shn converter mac, convert shn, convert shn to flac, play shn. Shorten (SHN) is a lossless compression format and is used to losslessly compress CD-quality audio files (44.1 kHz 16-bit stereo PCM). It can compact files without losing quality. Shn converter windows 10.

IMPORTANT SAFETY INFORMATION

• If cats have pale mucous membranes and unacceptably slow pulses (less than 80 bpm) or hypotension - stimulate them by handling and if this does not resolve the problem administer 10 to 20% of the calculated atipamazole dose IM. If you feel that the cat is in crisis, the full atipamazole dose can be given IV slowly by titration over 2.
• INDICATIONS: SILEO is indicated for the treatment of noise aversion in dogs. DOSAGE AND ADMINISTRATION: SILEO is administered onto the oral mucosa between the dog's cheek and gum at the dose of 125 mcg/m2. The gel is absorbed through the oral mucosa and therefore it should NOT be swallowed. If the gel is swallowed, the product may not be.

A silent disease

Sileo is packaged in an oral dosing syringe with a ring-stop mechanism on the plunger that must be 'dialed' and locked into place in order to set the correct dose for the dog. Overdose can. Sileo Indications. SILEO is indicated for the treatment of noise aversion in dogs. Dosage and Administration. Always provide the Client Information Sheet with SILEO and instruct the client how to properly operate the SILEO dosing syringe (see Client Information Sheet for Owner/Handler Use and Safety).

While hypertension can be a common problem in older cats, the condition can be difficult to diagnose.^3,4

Hypertension can affect many parts of the body before detection and is strongly associated with target organ damage^3,4:

• Eyes
• Heart and vascular system
• Brain
• Kidneys

Without treatment, this silent disease can lead to serious illness and, sometimes, death.^3,4

Most often develops as secondary hypertension to diseases such as CKD and hyperthyroidism.³

Efficacy

Proven to lower systolic blood pressure^1,10

A pilot dose determination laboratory study was conducted to evaluate the effectiveness of multiple oral doses and dose strategies of telmisartan on the reduction of systolic blood pressure (SBP) in clinically normal, healthy laboratory cats within a 14-day time period.¹¹

* Endpoint at day 14 was significant reduction from baseline compared to placebo (P < 0.0005).

† A clinically relevant reduction in group mean SBP was predefined to be ≥ 20 mmHg in the telmisartan group from baseline to Day 28. The number of cats available at Day 28 for comparison is less than at enrollment because of removal of cats for hypertension rescue or adverse reactions.

The only angiotensin receptor blocker (ARB) for first-line treatment of hypertension in cats

Sileo For Dogs Reviews

Because ARBs feature a unique, targeted mode of action that specifically blocks the harmful vasoconstrictive effects of the renin-angiotensin-aldosterone system (RAAS), SEMINTRA is shown to quickly lower blood pressure within 14 days‡

• Shown to be effective in cats with primary and secondary hypertension
• Proven to be safe and effective^10–13

Safety and Dosing

Flexible dosing to safely lower and maintain blood pressure in cats

• SEMINTRA offers a dose-dependent response—an initial 1.5 mg/kg (0.68 mg/lb) dose twice daily for 14 days lowers blood pressure to a healthy level quickly, followed by a 2 mg/kg (0.91 mg/lb) once daily dose to maintain control¹¹
• Dose may be reduced by 0.5 mg/kg (0.23 mg/lb) increments to a minimum of 0.5 mg/kg to optimize dosing and prevent hypotensive state

Easily given as oral liquid

Easy-to-use Syringe

— Flexible delivery of dose straight into the mouth or on top of food²

— Selection of accurate dose

Safe for long-term administration

— Safety shown to extend through 6 months in multiple studies^10–13

Convenient liquid formulation

As demonstrated in a study:

— 91.2% of cat owners perfer a liquid formulation²

Mode of Action

Sileo Side Effects

SEMINTRA is a highly targeted treatment

Telmisartan, the active substance in SEMINTRA, is an ARB, a class of medication that modulates the RAAS by selectively blocking receptors in the effector step of the RAAS. Unlike angiotensin-converting enzyme inhibitors (ACEis), ARBs do not block the conversion of angiotensin I to angiotensin II by angiotensin-converting enzyme in the RAAS cascade, thereby also blocking the activation of some of the receptor types with beneficial effects. And, unlike a calcium channel blocker, a class of pharmaceuticals that block the influx of calcium into cardiac and smooth muscle cells through calcium channels and potentially activate the RAAS, ARBs help to manage the RAAS.

Chronic activation of the RAAS can be harmful to tissues, including the kidney.

Watch this video for more information

• Activation of RAAS can be complex, but conditions like chronic kidney disease, cardiac disease, and hyperthyroidism typically increase RAAS activity
• Chronic, excessive RAAS activation can result in systemic hypertension because it promotes salt and water retention and increases blood pressure^14,15
• ACEis reduce the conversion of circulating angiotensin I to angiotensin II, which reduces all of the effects of angiotensin II at all receptors
• ARBs have a more targeted mode of action. They bind only to the AT₁ receptor, preventing activation of this receptor by angiotensin II
• Because ARBs do not bind to AT₂ receptors, the potentially beneficial effects of angiotensin II at these receptors are preserved

Sileo Dose In Cats Food

Watch this video for more information

Target-specific mode of action of ARBs

Shorten (SHN) is a file format used for compressing audio data. It is a form of data compression of files and is used to losslessly compress CD-quality audio files (44.1 kHz 16-bit stereo PCM). Shorten is no longer developed and other lossless audio codecs such as FLAC, Monkey's Audio(APE), TTA, and WavPack (WV) have become more popular. Jul 20, 2015 To complete the above tasks, Faasoft's wonderful SHN Converter for Mac and Windows is a nice choice. With the help of this powerful SHN Converter, you can convert SHN files to FLAC, MP3, WAV, M4A, AIFF, ALAC, CAF, DTS, AAC, etc effortlessly. Jul 09, 2020 shn to flac converter free download. Fre:ac - free audio converter fre:ac is a free audio converter and CD ripper for various formats and encoders. It features MP3, MP. Shn converter free download - MediaHuman YouTube to MP3 Converter, Free YouTube Converter, Xilisoft Video Converter Ultimate, and many more programs. Tags: shn to flac, shn to mp3, shn converter, shn to wav, convert shn to mp3, shn converter mac, convert shn, convert shn to flac, play shn. Shorten (SHN) is a lossless compression format and is used to losslessly compress CD-quality audio files (44.1 kHz 16-bit stereo PCM). It can compact files without losing quality. Shn converter windows 10.

IMPORTANT SAFETY INFORMATION

• SEMINTRA is for oral use in cats only.
• The most common side effects reported in field studies include vomiting, diarrhea, lethargy, dehydration, poor appetite, and weight loss. If side effects should occur, pet owners should contact their veterinarian. Click here for full prescribing information.
• SEMINTRA has not been evaluated in cats with systolic blood pressure > 200 mmHg. The safe use of SEMINTRA has not been evaluated in cats with hepatic disease, cats less than 9 months of age, or cats that are pregnant, lactating, or intended for breeding.
• The safe use of SEMINTRA with other anti-hypertensive medications has not been evaluated.
• Mild anemia or non-regenerative anemia has been reported.
• Pregnant women should avoid contact with SEMINTRA because substances that act on the renin-angiotensin-aldosterone system (RAAS), such as angiotensin receptor blockers (ARBs), can cause fetal and neonatal morbidity and death during pregnancy in humans.
• Not for human use. Keep out of reach of children. If SEMINTRA is accidentally ingested, contact a physician.
• SEMINTRA is a clear, colorless to yellowish viscous solution containing 10 mg/mL telmisartan.

Sileo For Cats

References:1. SEMINTRA^® (telmisartan oral solution) Prescribing Information. Boehringer Ingelheim Vetmedica, Inc. 2018. 2. Zimmering T. Ease of use of SEMINTRA and its effects on quality of life—update on cat owner feedback ('EASY Programme') [abstract]. In: Proceedings from the 21st Federation of European Companion Animal Veterinary Associations (FECAVA); October 15–17, 2015; Barcelona, Spain. Poster. 3. Elliott J, Fletcher M, Syme HM. Idiopathic feline hypertension: epidemiologic study [abstract]. J Vet Intern Med. 2003;17:754. 4. Taylor SS, Sparkes AH, Briscoe K, et al. ISFM Consensus Guidelines on the diagnosis and management of hypertension in cats. J Feline Med Surg. 2017;19(3):288–303. 5. Maggio F, DeFrancesco TC, Atkins CE, et al. Ocular lesions associated with systemic hypertension in cats: 69 cases (1985–1998). J Am Vet Med Assoc. 2000;217:695–702. 6. Littman MP. Spontaneous systemic hypertension in 24 cats. J Vet Intern Med. 1994;8:79–86. 7. Stiles J, Polzin D, Bistner SI. The prevalence of retinopathy in cats with systemic hypertensionand chronic renal failure or hyperthyroidism. J Am Anim Hosp Assoc. 1994;30:564–572. 8. Syme HM, Barber PJ, Markwell PJ, et al. Prevalence of systolic hypertension in cats with chronic renal failure at initial evaluation. J Am Vet Med Assoc. 2002;220:1799–1804. 9. Kobayashi DL, Peterson ME, Graves TK, et al. Hypertension in cats with chronic renal failure orhyperthyroidism. J Vet Intern Med. 1990;4:58–62. 10. Coleman AE. Efficacy of oral telmisartan for the treatment of systemic hypertension in cats. In: Proceedings from the American College of Veterinary Internal Medicine; June 14–16, 2018; Seattle, WA. Abstract RRS08-E. 11. Coleman AE, Brown SA, Stark M. Evaluation of orally administered telmisartan for the reduction of indirect systolic arterial blood pressure in awake, clinically normal cats [published online ahead of print March 7, 2018]. 12. Glaus AM, Elliott J, Albrecht B, et al. Efficacy of telmisartan in hypertensive cats: results of a large European clinical trial [abstract]. J Vet Intern Med. 2018;32:577. 13. SEMINTRA^® (telmisartan oral solution) [Freedom of Information Summary]. St. Joseph, MO: Boehringer Ingelheim Vetmedica, Inc.; 2018. J Feline Med Surg. doi:10.1177/1098612X18761439. 14. Williams TL, Elliott J, Syme HM. Renin-angiotensin-aldosterone system activity in hyperthyroid cats with and without concurrent hypertension. J Vet Intern Med. 2013;27(3):522–529. 15. Syme H. Hypertension in small animal kidney disease. Vet Clin North Am Small Anim Pract. 2011;41(1):63–89.

Sileo Dose In Cats Symptoms

Important Safety Information: Do not use SILEO in dogs with severe cardiovascular disease, respiratory, liver or kidney diseases, or in conditions of shock, severe debilitation, or stress due to extreme heat, cold or fatigue or in dogs hypersensitive to dexmedetomidine or to any of the excipients. SILEO should not be administered in the presence of preexisting hypotension, hypoxia, or bradycardia. Do not use in dogs sedated from previous dosing. SILEO has not been evaluated in dogs younger than 16 weeks of age or in dogs with dental or gingival disease that could have an effect on the absorption of SILEO. SILEO has not been evaluated for use in breeding, pregnant, or lactating dogs or for aversion behaviors to thunderstorms. Transient pale mucous membranes at the site of application may occur with SILEO use. Other uncommon adverse reactions included emesis, drowsiness or sedation. Handlers should avoid direct exposure of SILEO to their skin, eyes or mouth. Failure to lock the ring-stop on the syringe before dosing SILEO could potentially lead to an accidental overdose. Always review INSTRUCTIONS FOR USE before dispensing and dosing. See full Prescribing Information.